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Prednisone: Treating Various Diseases

Prednisone is a corticosteroid drug that is also used in chemotherapy. Therapy with this drug can be done in a clinic, hospital, or even at home. As a rule, it is prescribed in combination with other medications. In addition, prednisone can be used to treat inflammation, allergies and asthma, skin rashes, and adrenal dysfunction.

Prednisone is an inactive substance that enters the liver. It is converted into an active metabolite, prednisolone, after being absorbed from the gastrointestinal tract. Plasma protein binding of prednisolone is 90%.

Function

This drug works this way:

  • Suppresses the function of leukocytes and tissue macrophages.

  • Limits the migration of leukocytes to the area of inflammation.

  • Promotes the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation.

  • Reduces capillary permeability due to the release of histamine. Suppresses fibroblast activity and collagen formation.

Prednisone has anti-inflammatory, anti-allergic, immunosuppressive, and antiproliferative properties. It additionally often has a membrane-stabilizing effect, affects the lymphatic tissue, and causes a decrease in the number of lymphocytes. This medication is effective against cells of mesenchymal origin, i.e., it inhibits the growth of fibroblasts, collagen synthesis.

Proposed Clinical Use

In the case of oral and parenteral intake, there are the particular indications:

  • Rheumatism.

  • Rheumatoid arthritis.

  • Hepatitis, hepatic coma, hypoglycemic conditions.

  • Various forms of leukemia.

  • Eczema, exfoliative dermatitis, psoriasis.

For intra-articular administration, people with such diseases should use it: chronic polyarthritis, post-traumatic arthritis, osteoarthritis of large joints, rheumatic lesions of individual joints, arthrosis.

Contraindications

For short-term treatment for health purposes, the principal contraindication is hypersensitivity to prednisolone. There are additionally contraindications for intra-articular dose and injection directly into the lesion: former arthroplasty, pathological bleeding, intra-articular bone fracture, an infectious inflammatory process in the joint, and periarticular viruses. For external use:

  • Bacterial, viral, fungal skin diseases.

  • Dermis tuberculosis.

  • Skin manifestations of syphilis.

  • Epidermis tumors.

  • Post-vaccination period.

You should not take medicine if there is an enhanced sensitivity to prednisone, gastric ulcer and duodenal ulcer in the acute stage, osteoporosis, a tendency to thromboembolism, renal failure, severe arterial hypertension.

Forms of release and dosage

This steroid is a prescription drug available from many pharmacies. The drug is available in the form of immediate-release tablets. There is also a variant of delayed-release tablets. No less popular is an option in the form of a liquid solution. All of these forms are taken orally.

The dosage regimen is set individually, depending on the indications, the clinical situation, the patient’s age, and the dosage form.